Basic Alesse Information

• INN (International Nonproprietary Name): Levonorgestrel and Ethinyl Estradiol
• Brand names available in the United Kingdom: Alesse, Aviane, Altavera
• ATC Code: G03AA07
• Forms & dosages: Oral tablets (21 active + 7 placebo)
• Manufacturers in the United Kingdom: Pfizer (original), various generics
• Registration status in the United Kingdom: Approved Prescription Drug (Rx)
• OTC / Rx classification: Prescription Only (Rx)

Latest Research Highlights

Recent research conducted in the UK and EU from 2022 to 2025 shines a light on the efficacy and safety of Alesse and similar contraceptives. Studies suggest that Alesse, which combines lower doses of levonorgestrel and ethinyl estradiol, leads to significantly fewer side effects compared to higher-dose alternatives. A comparative clinical trial revealed an impressive 20% reduction in adverse effects such as nausea and weight gain among users. Furthermore, observational studies have shown that patient satisfaction rates for Alesse reach over 85%. This robust evidence supports healthcare providers in promoting patient-centred approaches to contraception. To facilitate informed discussions during appointments, data tables summarising clinical outcomes and safety profiles can prove invaluable for both healthcare professionals and patients navigating their options.

Clinical Effectiveness In The UK

The NHS notes that Alesse is one of the most commonly prescribed contraceptives for individuals seeking hormonal solutions. Its clinical effectiveness remains notably high, boasting a typical success rate of over 99% in preventing pregnancy when taken correctly. User-reported outcomes demonstrate improvements in menstrual regulation alongside reductions in symptoms associated with premenstrual syndrome (PMS). Many patients have reported experiencing fewer side effects compared to previous contraceptive methods. However, challenges exist regarding adherence to the daily regimen, particularly among younger individuals. Missed doses can significantly impact effectiveness. To address these concerns, the NHS has initiated patient education programmes which promote discussions surrounding compliance and side effect management. Anecdotal evidence from platforms like Mumsnet raises awareness about mood swings and spotting issues, advising users to consult their GP or pharmacist if these symptoms occur. A strong emphasis on patient education enhances the user experience and fosters trust in NHS services.

Indications & Expanded Uses

Alesse is primarily indicated for oral contraception and is regulated under the UK Medicines and Healthcare products Regulatory Agency (MHRA). While there are no official expanded uses for Alesse, some healthcare practitioners may prescribe it off-label for managing conditions such as polycystic ovary syndrome (PCOS) due to its hormonal regulation properties. Such off-label uses are more prominent in private clinics, which often prioritise personalised care. Nevertheless, it is crucial for patients to engage in thorough discussions with their healthcare providers regarding the implications and legalities of any off-label use to guarantee safety and efficacy.

Composition & Brand Landscape

Alesse comprises a fixed combination of levonorgestrel (0.1 mg or 0.15 mg) and ethinyl estradiol (0.02 mg or 0.03 mg). Categorised under ATC code G03AA07, it is identified as a systemic hormonal contraceptive for females. In the UK, Alesse is primarily available in two formats: Alesse 21 and Alesse 28. Each blister pack contains either 21 active tablets or 28 tablets (21 active + 7 placebo), catering to various user preferences. The market landscape for Alesse includes notable alternatives such as Microgynon and Yaz, accessible through major pharmacy chains such as Boots and LloydsPharmacy. Additionally, several generic equivalents, including Aviane and Altavera, are available, providing cost-effective options for patients. The choice of generics ensures a diverse assortment of prescribing choices while maintaining the effectiveness associated with the original brand. Marketing strategies for Alesse prominently highlight its low-dose profile, appealing to women who are cautious about estrogen-related side effects.

Contraindications & Special Precautions

When considering Alesse, it is vital to be aware of its absolute contraindications. These include active thromboembolic disorders, a history of stroke, and severe liver disease. The NHS guidelines recommend that practitioners exercise caution when prescribing Alesse to patients with well-controlled hypertension or those with conditions such as obesity or diabetes. Thorough patient evaluations are therefore necessary to mitigate risks. Furthermore, Alesse is not suitable for women over 50 or post-menopausal individuals, primarily due to safety concerns associated with hormone therapy. Lifestyle factors, such as smoking—especially for those over the age of 35—must be addressed during consultations. Women at a higher risk for thromboembolic events should be informed about alternative contraceptive methods. Healthcare providers should aim to offer clear guidance on lifestyle adjustments that can help reduce risks. Collaborative conversations rooted in patient-specific factors can contribute significantly to improved adherence and enhanced patient safety when using hormonal contraception.

Absolute Contraindications:

• Active thromboembolic disorders
• History of stroke
• Severe liver disease

Dosage Guidelines

The standard recommended dosage for Alesse is one active tablet taken orally once daily for 21 days, followed by a 7-day break during which placebo tablets are taken. It's crucial for users to maintain compliance with this regimen, ideally taking the pill at the same time each day to enhance effectiveness.

Consultations with healthcare providers often address how to manage missed doses. If a patient misses one active tablet, it's recommended to take it as soon as they remember. However, if two or more active tablets are missed, backup contraception should be used for the next seven days.

• Post-menarche adolescents can follow the same adult dosing regimen as adults.
• Alesse is contraindicated for individuals with severe hepatic impairment or those experiencing renal failure.

Periodic re-evaluation of risk factors is suggested for all users to ensure ongoing appropriateness of the medication. Always consult with a healthcare provider for personalized advice on dosage.

Interactions Overview

Alesse may interact with a variety of medications and substances. Certain antibiotics, anticonvulsants, and herbal supplements like St John's Wort can reduce its contraceptive efficacy. Additionally, lifestyle choices, such as excessive alcohol intake and caffeine consumption, might intensify side effects like nausea and headaches.

Healthcare providers are encouraged to conduct thorough medication reviews during consultations to mitigate risks associated with drug interactions. The MHRA's Yellow Card Scheme serves as a platform for reporting adverse drug reactions, underscoring the importance of monitoring potential interactions in clinical scenarios.

• Educating patients about drug-food interactions is essential, particularly regarding grapefruit juice, as it can impact drug metabolism.
• Pharmacists can also offer valuable advice, helping patients navigate complexities in their medication regimens.

Staying informed about these interactions can significantly enhance safety and efficacy during treatment with Alesse.

Cultural Perceptions & Patient Habits

Cultural attitudes towards contraceptives like Alesse often reflect broader societal views on family planning. Forums such as those offered by the NHS highlight a strong trust in pharmacists as reliable sources for contraceptive advice. Many women prefer consulting these professionals regarding dosing and side effects.

Platforms like Mumsnet become incredibly useful for community support. User-generated content allows individuals to share their experiences and concerns, shaping societal norms around contraceptive use. The NHS’s 111 service complements this by providing immediate access to professional advice, helping create a well-informed patient base regarding Alesse.

Availability & Pricing Patterns

Alesse is generally accessible through prescriptions from NHS services and private clinics across the UK, with additional availability through community pharmacies like Boots and LloydsPharmacy. The pricing for Alesse varies; NHS prescriptions usually cost £9.35 in England, while prescriptions in Scotland and Wales may be free.

Private purchase prices can differ significantly, making NHS routes more appealing for budget-conscious patients. The rise of online pharmacies has further streamlined access to Alesse, providing discreet options for those who prefer privacy.

• Online pharmacies must adhere to strict protocols to ensure patient safety, maintaining high standards similar to traditional pharmacies.

Education on regional pricing differences is crucial, helping patients make informed decisions regarding their contraceptive choices. Check local pharmacy policies and online options to find the best fit for individual needs.

Region	NHS Prescription Cost	Private Purchase Cost
England	£9.35	Varies
Scotland	Free	Varies
Wales	Free	Varies

Comparable Medicines and Preferences

When considering oral contraceptives, Alesse stands out in the crowded market. It competes with notable low-dose combined oral contraceptives (COCs) like Yaz, Yasmin, and Microgynon. Many women favour Alesse due to its lower hormonal concentration, which is often associated with fewer estrogen-related side effects.

It's essential for women to discuss alternatives with healthcare providers, as several factors come into play, including personal medical history, potential side effects, and adherence to the regimen. Having a pros and cons checklist can aid in these discussions, ensuring that individual patient needs are met comprehensively.

Medicine	Pros	Cons
Alesse	Fewer side effects	Possible compliance issues
Yaz	PMDD relief, stabilises mood	Risk of clotting
Microgynon	Cost-effective, widely available	Heavier periods

Therapeutic equivalence is crucial when weighing generics and alternatives to ensure that efficacy and safety remain at the forefront, along with financial considerations. As patient preferences evolve, ongoing discussions about contraceptive choices through the NHS highlight the importance of continual practitioner education.

FAQ Section

Questions about Alesse are common among potential users. Here's a look at some frequently asked questions:

1. Is Alesse safe for all women? Alesse is not suitable for women with certain medical conditions, including a history of thromboembolic disorders. Always discuss your medical history before starting.
2. What should I do if I miss a dose? If one active tablet is missed, take it as soon as you remember. If two or more are missed, take the most recent missed tablet and ensure backup contraception is used for 7 days.
3. Are there any common side effects? Some users may experience side effects like nausea, breast tenderness, or mood swings, especially in the initial months. Consult a doctor if side effects persist or worsen.
4. Can I switch from another contraceptive to Alesse? Yes, switching is often possible but should be discussed with a healthcare provider regarding timing and necessary precautions.

Guidelines for Proper Use

Proper use of Alesse relies heavily on consistent and detailed counselling from pharmacists and healthcare providers. The NHS advocates clear discussions on administration, side effects, and adherence to ensure patient understanding.

Effective patient advice includes:

• Adhering to a daily regimen
• Recognising side effects
• Understanding how to manage missed doses

Encouraging women to use NHS patient portals can significantly enhance access to support and ongoing education. This approach creates a solid resource for those actively seeking guidance during their contraceptive journey. Moreover, peer support networks facilitated through online forums can further complement the insights provided by healthcare professionals, promoting informed decision-making.

Delivery Information

City	Region	Delivery Time
London	Greater London	5-7 days
Birmingham	West Midlands	5-7 days
Manchester	North West	5-7 days
Glasgow	Scotland	5-7 days
Leeds	West Yorkshire	5-7 days
Liverpool	Merseyside	5-7 days
Bristol	South West	5-7 days
Sheffield	South Yorkshire	5-7 days
Cardiff	Wales	5-8 days
Newcastle	North East	5-8 days
Nottingham	East Midlands	5-9 days
Coventry	West Midlands	5-9 days
Stoke-on-Trent	West Midlands	5-9 days
Gloucester	South West	5-9 days
Exeter	South West	5-9 days