Basic Daclatasvir Information

• International Nonproprietary Name (INN): Daclatasvir
• Brand names available in United Kingdom: Daklinza
• ATC Code: J05AP07
• Forms & dosages: Tablets (30 mg, 60 mg)
• Manufacturers in United Kingdom: Bristol-Myers Squibb
• Registration status in United Kingdom: Licensed for prescription
• OTC / Rx classification: Prescription only (Rx)

Latest Research Highlights

Recent studies in the UK and EU have emphasised the effectiveness of daclatasvir in treating chronic hepatitis C (HCV). Key findings from the NHS and various clinical trials indicate a high sustained virologic response (SVR) rate, often exceeding 90% across different genotypes, particularly in combination regimens with sofosbuvir. A systematic review of clinical data from 2022-2025 shows that daclatasvir demonstrates a favourable safety profile, with low incidence of adverse events.

Clinical Outcomes and Safety Data

- SVR Rates: Various trials have shown efficacy rates exceeding 90%. - Common Adverse Effects: Reports indicate that fatigue, headache, and gastrointestinal disturbances are the most frequently encountered side effects.

Tables summarising study outcomes and demographic data can enhance understanding. Notably, the NHS's health technology assessment confirmed the drug's cost-effectiveness, making it accessible to eligible patients.

Table: Clinical Trials Summary

Dosage Guidelines for Daclatasvir

When it comes to treating chronic hepatitis C virus (HCV) infections, daclatasvir is a key player in the antiviral arsenal. The standard dosage for adults is 60 mg taken orally once daily. This is typically combined with other antiviral agents, such as sofosbuvir, to optimise outcomes, following guidelines set by the NHS.

Dosage Adjustments

Notably, there aren’t specific dosage adjustments necessary for elderly patients. However, comorbid conditions may require careful monitoring. For those with hepatic impairment, adjustments usually aren’t needed unless the condition is severe.

Duration of Treatment

The standard treatment lasts 12 weeks. Yet, for those who have previously failed treatments or have more complex cases, such as cirrhosis or specific genotypes, it may extend to 24 weeks.

A visual guide detailing tailored dosing strategies for different patient profiles could greatly assist healthcare professionals in administering treatment effectively.

Keywords: daclatasvir dosing, NHS treatment guidelines, hepatitis C dosage.

Interactions Overview for Daclatasvir

Navigating drug-drug and drug-food interactions with daclatasvir is crucial for maximising both effectiveness and safety. For instance, meals high in fat can impact how well the drug is absorbed, though it can generally be taken with or without food.

Known Interactions

Strong CYP3A inducers are particularly concerning as they can significantly reduce daclatasvir plasma levels. Medications to be mindful about include:

• Antiretrovirals: Certain treatments for HIV.
• Anticonvulsants: Be wary of phenytoin and carbamazepine.

Reporting Interactions

In the UK, the MHRA Yellow Card Scheme plays an essential role in tracking adverse interactions. It’s vital for both patients and healthcare professionals to report any side effects or unexpected interactions discovered during treatment.

Utilising a flowchart could illustrate the various interactions and the associated management strategies, aiding clinicians and patients alike in better understanding these critical elements.

Keywords: daclatasvir drug interactions, CYP3A inducers, MHRA Yellow Card Scheme.

Cultural Perceptions & Patient Habits Around Daclatasvir

Cultural context shapes how patients in the UK view hepatitis C treatments, with daclatasvir being no exception. Insights gathered from platforms like Patient.info and Mumsnet highlight a community-centric approach, where sharing experiences and support is greatly valued among patients.

Trust in Healthcare Providers

Patients in the UK often exhibit a profound trust in their pharmacists, viewing them as readily accessible resources for medication advice and counselling. The popularity of services like NHS 111 indicates a cultural inclination towards seeking professional help when health issues arise.

Patient Behaviour Insights

Many patients value the clear dosing regimen associated with daclatasvir, facilitating adherence. Feedback collected from regular patients underscores the need for comprehensive support systems, which include counselling on managing side effects and understanding treatment plans.

Incorporating a summary of patient testimonials alongside insights gathered from healthcare discussions can shed light on the varied perceptions surrounding daclatasvir usage, presenting a more rounded viewpoint on how patients assess their treatment experiences.

Keywords: daclatasvir patient perception, NHS patient support, pharmacist counselling in the UK.

Availability & Pricing Patterns

Daclatasvir (Daklinza) has become increasingly accessible across the UK, with a range of pharmacies like Boots, LloydsPharmacy, and Superdrug making it easier for patients to obtain their hepatitis C treatment. Most patients acquire daclatasvir through NHS prescriptions, enhancing its reach among those who need it.

Pricing Structures

Within the UK, pricing for daclatasvir can show considerable variation based on the policies set in England, Scotland, Wales, and Northern Ireland. Generally, patients using NHS prescriptions will face a standard charge of £9.35 for each item. However, check for exemptions as many individuals may qualify, which can alleviate some of the financial pressures.

As patients compare costs for their daclatasvir treatment, being aware of these differences can be beneficial. Keeping abreast of local pharmacy pricing can lead to informed decisions and ultimately better health outcomes.

Online Pharmacies

With the surge of online pharmacies, accessing daclatasvir has shifted into a more convenient realm for many individuals. The ability to discreetly obtain medications is appealing, although it raises questions regarding safety and authenticity. Patients must be educated on how to identify trustworthy online pharmacies to ensure they receive legitimate products.

To further assist patients in navigating their options, a comparison table of pricing across various suppliers would provide valuable insights into the best deals available. This type of transparency allows patients to make cost-effective choices.