Basic Microzide Information

Category	Details
INN (International Nonproprietary Name)	Hydrochlorothiazide
Brand names available in United Kingdom	Microzide, Aquazide H, Hydrochlorothiazide, Hydrodiuril
ATC Code	C03AA03
Forms & dosages	Capsules (12.5 mg), Tablets (12.5, 25, 50 mg)
Manufacturers in United Kingdom	Sandoz, Teva
Registration status in United Kingdom	Approved for prescription use
OTC / Rx classification	Prescription only

Latest Research Highlights

Recent studies from the UK and EU conducted between 2022 and 2025 provide valuable insights into Microzide, known generically as Hydrochlorothiazide, and how it is applied clinically. Notably, a significant trial undertaken by the NHS highlighted promising results in managing hypertension among individuals aged 40-70. An impressive 75% of participants managed to achieve their target blood pressure (BP) levels, which is defined as below 140/90 mmHg, particularly when Microzide was used alongside beneficial lifestyle modifications. Adding to the body of research, a meta-analysis published in the *European Heart Journal* in 2023 assessed the safety profile of Hydrochlorothiazide, revealing a low incidence of severe adverse reactions, particularly in older adults. This analysis also emphasised the necessity of routinely monitoring patients' electrolyte levels. Hypokalemia emerged as the most concerning side effect, with approximately 10% of patients affected by this condition. Such findings are essential as they guide clinicians in their patient management strategies, especially when considering long-term use and the need for dosage adjustments to fit individual patient profiles.

Data Highlights

• Target BP achievement in 75% of patients.
• Hypokalemia incidence rate of 10%.

Contraindications & Special Precautions

When it comes to taking Microzide, also known as Hydrochlorothiazide, it’s crucial to understand the conditions that might make this medication unsuitable for certain individuals. Absolute contraindications are clear-cut: those with anuria, a severe inability to urinate, and anyone with a known hypersensitivity to Hydrochlorothiazide should steer clear. Adding to the list, concurrent usage with dofetilide or lithium can lead to severe interactions, which can be harmful.

For those managing chronic conditions like gout, diabetes, or renal impairment, vigilance is vital. Adjustments might be necessary, and monitoring electrolyte levels becomes a routine part of treatment, especially in the elderly population. These patients should start at the lowest effective dose to reduce the risk of potential side effects.

Among the common side effects is increased urination, which may lead to dehydration, and dizziness due to changes in blood pressure. An unsettling thought, but understanding these risks is part of managing your health.

• Regularly monitor electrolyte levels.
• Adjust doses for high-risk groups, including the elderly and those with renal issues.

Dosage Guidelines

Following the NHS guidelines, Microzide treatment for hypertension typically begins at a daily dose of 12.5–25 mg taken orally. In cases where edema is a concern, dosages ramp up to between 25–100 mg, often administered in one or two divided doses. For children, it’s a tailored approach based on body weight, generally falling in the 1–2 mg/kg range, which requires a paediatric specialist's oversight.

It's particularly important to note that elderly patients or those with renal impairment may require dose adjustments, especially if their estimated glomerular filtration rate (eGFR) is below 30 ml/min. Regular reviews are essential to ensure ongoing treatment effectiveness while also mitigating associated risks.

Key considerations include:

• Start patients on lower doses and adjust based on their response.
• Conduct regular reviews to tailor ongoing treatment plans.

Interactions Overview

Microzide isn't alone in the realm of drug interactions—patients should be aware that alcohol can heighten side effects such as dizziness or hypotension while taking this medication. Furthermore, certain substances like NSAIDs and corticosteroids can disrupt electrolyte balance and impact renal function.

The MHRA places importance on monitoring such interactions and routinely reviews them to ensure patient safety, especially for those on multiple medications. Counseling patients about dietary interactions, particularly high potassium foods, is also critical as these can additionally alter electrolyte levels.

• Be vigilant for signs of hypotension when consuming alcohol.
• Review all concomitant medications to identify potential interaction risks.

Cultural Perceptions & Patient Habits

In the UK, there's a notable cultural inclination toward pharmacist counselling, especially in relation to Microzide. Discussions on forums like Patient.info and Mumsnet highlight how patients frequently view pharmacists as trusted advisors for medication guidelines, particularly regarding Hydrochlorothiazide’s effects on hypertension management.

Patients favour engaging with NHS services, including NHS 111, to get advice before addressing side effects or medication concerns. This trend signifies a shift towards a participatory method in health management, where patients feel motivated to speak openly about their experiences while on Microzide.

Insights from this cultural landscape reveal:

• A strong trust in pharmacist advice.
• A preference for exploring natural remedies in tandem with prescribed medications.

Availability & Pricing Patterns

Access to Microzide is quite straightforward in the UK, primarily through several well-known pharmacy chains such as Boots, LloydsPharmacy, and Superdrug. The presence of these major players in the healthcare market ensures that Hydrochlorothiazide, the active ingredient in Microzide, is readily available to patients who need it.

The NHS pricing structure for prescription medications, including Microzide, is consistent across England, Scotland, Wales, and Northern Ireland. However, some variations may arise from regional dispensary fees. This standardisation helps patients know what to expect when filling their prescriptions.

In recent years, there has been a noticeable shift towards privatization within the healthcare sector in the UK. This change has led to a burgeoning number of online pharmacies. These digital platforms often present a variable pricing structure, allowing patients to purchase Hydrochlorothiazide directly, frequently at competitive or even discounted rates. Such options are worth considering, especially given the potential for cost savings.

However, when deciding between NHS prescriptions and private purchases, patients should weigh several factors:

• Overall cost implications.
• Responsibility for stock and potential availability issues.
• Accessibility to required medications.

Access Overview

Microzide is accessible across a robust network that includes some of the most trusted pharmacy chains in the UK. Boots and Superdrug have made it easier for people to obtain Hydrochlorothiazide, ensuring that patients are not left without their medications, especially if online options are preferable.

The growth of online pharmacies has significantly impacted accessibility. Patients now have the choice to purchase medications from the comfort of their homes, adding convenience to their healthcare journeys. This shift has made purchasing Hydrochlorothiazide more accessible, allowing options that may suit varying needs and preferences.

Delivery Overview

City	Region	Delivery Time
London	Greater London	5–7 days
Birmingham	West Midlands	5–7 days
Manchester	Greater Manchester	5–7 days
Glasgow	Scotland	5–7 days
Leeds	West Yorkshire	5–7 days
Liverpool	Merseyside	5–7 days
Bristol	South West England	5–7 days
Sheffield	South Yorkshire	5–7 days
Newcastle upon Tyne	Tyne and Wear	5–7 days
Cardiff	Wales	5–7 days
Edinburgh	Scotland	5–7 days
Stoke-on-Trent	Staffordshire	5–9 days
Coventry	West Midlands	5–9 days
Nottingham	East Midlands	5–9 days