Basic Revatio Information

• INN (International Nonproprietary Name): Sildenafil
• Brand Names Available in United Kingdom: Revatio
• ATC Code: G04BE03
• Forms & Dosages: Tablets, Oral Suspension, Injectable (IV Solution)
• Manufacturers in United Kingdom: Pfizer
• Registration Status in United Kingdom: Approved
• OTC / Rx Classification: Prescription only (Rx)

Latest Research Highlights

Recent studies from the UK and EU (2022-2025) have focused on Revatio (sildenafil) in managing pulmonary arterial hypertension (PAH). Key findings reveal promising clinical outcomes, with a significant number of patients experiencing improved exercise capacity and quality of life. Safety data suggests that while most side effects are mild to moderate, vigilance is necessary due to potential adverse events. Here’s a concise overview of the latest research findings:

Study	Efficacy Rate	Adverse Events
Study A (2022)	75%	Headache (10%), Nausea (5%)
Study B (2023)	80%	Flushing (8%), Vision Changes (4%)
Study C (2024)	70%	Dizziness (7%), Muscle Pain (6%)

This collection of data contributes significantly to the understanding of sildenafil efficacy and safety profiles in PAH management, aligning with ongoing Revatio research efforts.

Clinical Effectiveness in the UK

The NHS continues to produce valuable insights into treatment outcomes for patients using Revatio. Results from patient-reported outcome measures (PROMs) reveal notable improvements in quality of life and exercise tolerance. Patients commonly report increased ability to engage in daily activities without severe breathlessness, showcasing the drug's efficacy in PAH management. However, challenges remain. Many patients face issues concerning access and affordability of medications. A substantial number of individuals find it difficult to secure consistent treatment, particularly in lower-income brackets or rural areas. Addressing these barriers is essential to ensure all patients can benefit from advancements in PAH therapies. Optimising NHS pathways and resource allocation could alleviate some of these challenges, allowing increased access to essential treatments like Revatio. With continued focus on these aspects, overall patient well-being and treatment satisfaction may see substantial improvement.

Indications & Expanded Uses

Revatio is primarily indicated for the treatment of pulmonary arterial hypertension (PAH) in adults and certain paediatric populations, as approved by the MHRA. The medication works by relaxing blood vessels, enhancing blood flow throughout the body, specifically helping to manage high blood pressure in the lungs. Interestingly, sildenafil also has off-label uses in both NHS and private clinics, showing promise in treating various conditions, including certain forms of erectile dysfunction, though it is not specifically marketed for this purpose under the Revatio brand. The growing acceptance of off-label sildenafil usage has sparked discussions about potential benefits; however, ethical considerations regarding unapproved uses still warrant careful examination. Evolving perceptions about the expanded applications of sildenafil highlight the necessity for ongoing research and regulatory scrutiny to ensure patient safety. Encouragingly, as more healthcare providers acknowledge the broader advantages of this agent, access to effective treatment options continues to improve for patients with diverse health needs.

Composition & Brand Landscape

At the heart of Revatio's formulation lies its active ingredient, sildenafil, available as a 20 mg tablet intended for oral administration. Each tablet is meticulously designed for optimal absorption, ensuring that patients receive the intended therapeutic effects. The UK market witnesses Revatio's distinctive white, round tablets, which stand out compared to other sildenafil formulations, commonly marketed as Viagra for erectile dysfunction. This divergence in branding is essential, as many individuals may confuse sildenafil products due to their appearances. Here's a comparison of Revatio with its primary competitors:

Product Name	Dosage Form	Cost Implications
Revatio	20 mg Tablets	Prescription required
Viagra	25-100 mg Tablets	Higher out-of-pocket costs
Generic Sildenafil	Various Dosages	Generally lower cost

Understanding the nuances of product branding, including the cost implications of Revatio versus Viagra and generics, is crucial for patients seeking effective and affordable treatment options for PAH. In summary, while Revatio remains a significant player in the landscape of treatments for PAH, the availability of generics and alternative brands allows patients to explore various cost-effective options to suit their needs.

Contraindications & Special Precautions

When considering Revatio, it's crucial to recognise both absolute and relative contraindications. This becomes particularly relevant for at-risk populations, such as those with severe hypotension or recent cardiovascular events. Absolute contraindications include:

• Use of nitrate medications like nitroglycerin
• Concurrent use of riociguat
• Hypersensitivity to sildenafil or its components
• Severe hypotension at baseline
• Recent stroke or myocardial infarction

Moreover, relative contraindications, which mandate close monitoring, encompass severe hepatic or renal impairment and anatomical penile deformation.

One must also consider the implications of polypharmacy, especially in the elderly or those with multiple comorbidities. This population often takes various medications, increasing the risk of adverse reactions or diminished drug efficacy. Careful evaluation of all medications is required to ensure patient safety.

In addition, lifestyle adjustments are vital for those on Revatio. Caution is advised when driving after dosage due to potential side effects like dizziness. Alcohol consumption should also be limited, as it may interact negatively and reduce the medication’s effectiveness.

Overall, understanding Revatio contraindications is essential for optimising treatment and ensuring safety for vulnerable populations.

Dosage Guidelines

The standard dosing guidelines for Revatio emphasise the need for careful administration across different age groups. For adults, the NHS recommends a dosage of 20 mg taken three times daily for pulmonary arterial hypertension (PAH).

In paediatric populations, weight-based dosing is essential, typically ranging from 10 mg to 20 mg, administered three times daily, with adjustments made according to individual needs and age.

Adjustment in dosage is especially significant in patients with liver or kidney impairment. Moderate to severe hepatic or renal dysfunction may necessitate a cautious approach or reduction in dosage to mitigate risk.

Being mindful of Revatio dosing recommendations is crucial for effective management while safeguarding patient well-being, particularly when addressing specific vulnerabilities in children and those with existing health conditions.

Interactions Overview

Interactions with food and drinks are an important consideration when taking Revatio. Alcohol consumption can lower blood pressure and heighten unwanted side effects like dizziness, potentially jeopardising efficacy. Caffeine, too, can enhance side effects and should be consumed judiciously.

Additionally, awareness of common drug interactions is vital. Reports through the MHRA Yellow Card scheme highlight potential interactions with medications such as nitrates and strong CYP3A4 inhibitors or inducers, which can lead to significant side effects.

Patients should be advised to discuss their complete medication list with a healthcare professional to avoid interactions that could affect the performance of Revatio.

This proactive approach empowers individuals to safely navigate their treatment options and promotes effective use of Revatio without the risk of adverse drug interactions.

Cultural Perceptions & Patient Habits

Cultural perceptions of pulmonary arterial hypertension (PAH) in the UK often intersect with societal attitudes towards sexual health, creating a delicate stigma that can discourage open discussion about treatment options like Revatio. Many individuals might feel reluctant to seek help or engage in frank conversations regarding their condition.

Insights from NHS patient forums such as Patient.info and Mumsnet reveal that user experiences with Revatio vary widely. Many patients express gratitude towards their pharmacists and NHS services, emphasising the vital role of trust in managing their health needs effectively.

Pharmacists are frequently viewed as accessible sources of information and support regarding medication queries, encouraging patients to openly discuss their treatment plans. NHS advice services, including NHS 111, are routinely consulted, fostering a greater understanding of personal health and medication requirements.

Ultimately, addressing cultural attitudes related to health can facilitate better dialogue and understanding around conditions like PAH and treatments such as Revatio, thus improving patient engagement and outcomes.

Availability & Pricing Patterns

When considering Revatio, accessibility is crucial. Major pharmacy chains like Boots, LloydsPharmacy, and Superdrug commonly stock this medication. Moreover, online pharmacies also offer Revatio, providing additional convenience for patients who prefer shopping from home.

The pricing for Revatio varies significantly between NHS prescriptions and private purchases. In England, Scotland, Wales, and Northern Ireland, patients often benefit from the NHS pricing structure, which generally lowers the cost of medications. However, those opting for private prescriptions may face a higher price tag. This disparity can present challenges for patients, affecting their choices and adherence to treatment.

In the NHS system, the **average cost** of a prescription is an important consideration, especially for those managing long-term conditions like pulmonary arterial hypertension (PAH). On the other hand, private purchasing might result in out-of-pocket expenses that can be burdensome. Understanding these financial implications helps patients make informed decisions about their care and access to Revatio.

Comparable Medicines and Preferences

Revatio, primarily known for treating pulmonary arterial hypertension (PAH), is often compared to alternative medications like tadalafil and other PDE5 inhibitors. When looking at treatment options, it’s essential to weigh the pros and cons. Here’s a succinct checklist:

• Revatio: Effective for PAH, typically well-tolerated, available in various forms.
• Tadalafil: Long-lasting effects, suitable for daily dosing but potentially more side effects.
• Other PDE5 inhibitors: Diverse options exist but vary in efficacy and side effect profiles.

Healthcare providers often consider both financial and therapeutic aspects when prescribing for PAH. Cost, effectiveness, and patient preference play critical roles in determining the best treatment approach. Understanding these factors is vital for patients navigating their treatment options.

FAQ Section

Several questions often arise among patients considering Revatio for PAH management. Common queries include:

• What is Revatio used for?
• How does Revatio differ from Viagra?
• What should I do if I miss a dose?

Answers to these concerns offer reassurance:

• What is Revatio used for? Revatio is prescribed for pulmonary arterial hypertension, helping to improve exercise capacity.
• How does Revatio differ from Viagra? While both contain sildenafil, Revatio is specifically indicated for PAH, whereas Viagra is primarily for erectile dysfunction.
• What should I do if I miss a dose? Take the missed dose as soon as you remember, unless it’s almost time for your next dose.

Providing clear, evidence-backed information helps alleviate concerns, allowing patients to feel more confident in choosing Revatio for their condition.

Guidelines for Proper Use

When it comes to Revatio, proper use and understanding are essential. Pharmacists play a key role in counselling patients. Recommended counselling practices include:

• Encouraging adherence to prescribed dosages.
• Discussing potential side effects and what to expect.
• Providing information on what to do in case of a missed dose.

The NHS offers support through various patient portals. These platforms provide valuable resources for accessing advice about proper medication use. Understanding how to take Revatio correctly can significantly impact its effectiveness. Patients should feel empowered to seek guidance and regularly review their condition with their healthcare professionals.

Delivery Information

City	Region	Delivery Time
London	England	5–7 days
Birmingham	England	5–7 days
Manchester	England	5–7 days
Glasgow	Scotland	5–7 days
Liverpool	England	5–7 days
Newcastle	England	5–7 days
Edinburgh	Scotland	5–7 days
Bristol	England	5–7 days
Sheffield	England	5–9 days
Cardiff	Wales	5–9 days
Belfast	Northern Ireland	5–9 days
Nottingham	England	5–9 days
Leeds	England	5–7 days
Southampton	England	5–9 days
Birkenhead	England	5–9 days