Basic Uniphyllin Information

• INN (International Nonproprietary Name): theophylline
• Brand Names Available in United Kingdom: Uniphyllin, Uniphyllin Continus
• ATC Code: R03DA04
• Forms & Dosages: Extended-release tablets (200 mg, 300 mg, 400 mg), syrup
• Manufacturers in United Kingdom: Teva, Sanofi
• Registration Status in United Kingdom: Prescription only (Rx)
• OTC / Rx Classification: Prescription required

Latest Research Highlights

Recent studies indicate a growing body of evidence supporting the efficacy of uniphyllin, particularly in managing chronic obstructive pulmonary disease (COPD) and asthma within UK populations. Research published between 2022 and 2025 demonstrates improvements in lung function and quality of life for patients using extended-release formulations. A recent UK-based randomised controlled trial noted a significant reduction in rescue medication use among patients on uniphyllin compared to placebo. A summary of key findings from clinical outcomes and safety data across various studies can be seen in the table below. These studies highlight the importance of serum monitoring, as variations in metabolism can significantly impact therapeutic efficacy and safety, especially among elderly patients and those with liver impairments.

Study	Outcome	Adverse Events
RCT 2022	Improved FEV1	Mild nausea in 15% cases
Long-term study 2023	Lower exacerbations	Insomnia reported
Meta-analysis 2024	Quality of life increase	Tremors in 8% patients

The need for proper monitoring is crucial, as uniphyllin's metabolism can vary greatly from patient to patient. This variability is particularly significant in older adults and those with liver issues, reinforcing that adherence to a well-monitored regimen is essential for maximising the benefits of this medication. Without proper oversight, there are potential risks that could detract from the treatment’s effectiveness. In summary, the latest research on uniphyllin illustrates its effectiveness particularly in COPD and asthma management, validating its inclusion as a vital therapeutic option within UK healthcare. The studies reveal not only enhancements in lung function but also improvements in the overall quality of life for users, spotlighting the importance of consistent and monitored use. Whether you are considering uniphyllin or currently using it, staying informed about its effects and adhering to monitoring protocols can enhance treatment outcomes significantly.

Contraindications & Special Precautions

Before starting uniphyllin, understanding its contraindications is crucial. This medication should be avoided by individuals known to have hypersensitivity to theophylline or other xanthines. Such reactions can lead to severe allergic responses, making it vital for healthcare providers to conduct thorough assessments.

Caution is particularly warranted in elderly patients, given their increased susceptibility to adverse reactions. The British National Formulary (BNF) recommends closer monitoring and possible dose adjustments for older adults. This demographic often encounters several comorbidities, such as severe liver or kidney disease and congestive heart failure, which necessitate special consideration when prescribing uniphyllin.

Additionally, patients with a history of arrhythmias should be carefully evaluated. The potential for exacerbating existing conditions exists, leading to further complications. As a best practice, any lifestyle changes—particularly regarding alcohol consumption—should be discussed with the patient to help manage risks associated with uniphyllin use.

Summarily, the following groups should approach uniphyllin with caution:

• Patients with history of hypersensitivity to theophylline or xanthines
• Elderly patients at higher risk of side effects
• Individuals with severe liver or kidney disease
• Those with congestive heart failure or arrhythmias

Dosage Guidelines

In the UK, NHS dosage guidelines stress the importance of personalising uniphyllin regimens based on patient-specific factors such as age, weight, and existing comorbidities. For adults beginning treatment, the starting dose is typically in the range of 300–400 mg once daily. However, adjustments may be necessary, especially for vulnerable populations such as the elderly or those with liver or kidney impairment.

For older adults, healthcare providers often recommend starting with a lower dose—about 300 mg—while monitoring serum theophylline levels closely before making any dosage increases. This approach helps mitigate the risks of side effects, a critical consideration given the unique physiological changes in older patients.

Table 1 below summarizes standard guidelines for dosages based on different patient categories:

Patient Group	Recommended Dosage
Adults (General)	300–400 mg daily
Elderly	Initial 300 mg; monitor closely
Liver/Kidney Impairment	Substantial dose reduction recommended

Adherence to prescription guidelines is paramount. Patients should be aware that stopping uniphyllin abruptly can lead to a worsening of respiratory symptoms, necessitating education on the importance of consistent medication intake.

Interactions Overview

Uniphyllin is known for its potential interactions that can significantly impact its effectiveness and the risk of side effects. A common concern is the interaction with caffeine. Consuming caffeine-containing beverages can lead to elevated theophylline levels, increasing its effects and potentially causing adverse events.

Drug interactions are another area of concern, particularly due to uniphyllin's metabolism via CYP450 enzymes. The concurrent use of certain medications, including antibiotics, anticonvulsants, or antidepressants, may necessitate careful monitoring by healthcare providers. Recommendations from the Medicines and Healthcare products Regulatory Agency (MHRA) highlight the importance of reporting any adverse interactions, contributing to safety enhancements for patients using uniphyllin.

Awareness of these interactions is vital for effective management of uniphyllin prescriptions and can greatly influence treatment outcomes. Both pharmacists and medical personnel must educate patients about potential drug and food interactions, ensuring a comprehensive understanding of safe medication use.

Cultural Perceptions & Patient Habits

The perception of uniphyllin within the UK healthcare landscape underscores the vital role that patient education and support play. NHS platforms frequently emphasise the importance of pharmacist counselling for optimised medication use. Online forums like Patient.info and Mumsnet foster an environment for sharing personal experiences regarding uniphyllin, illustrating the community's reliance on mutual support for navigating medication adherence challenges.

Local pharmacies, including well-known names like Boots and LloydsPharmacy, are trusted by patients as resources for discussing medication regimens and potential side effects openly. Discussions in these forums reveal that patients value transparency regarding uniphyllin's side effects and potential management strategies. This fosters enhanced patient-provider relationships and encourages a collaborative approach to medication management.

Ultimately, effective education not only promotes adherence to treatment but empowers patients to engage proactively in their healthcare decisions. By bridging the gap between healthcare providers and patients, cultural perceptions surrounding uniphyllin and its use become significantly more positive, reinforcing the medication's role in managing respiratory conditions.

Availability & Pricing Patterns

Uniphyllin's availability varies across major pharmacy chains like Boots, LloydsPharmacy, and Superdrug. While NHS prescriptions typically cover this medication, pricing differences can arise due to regional healthcare funding and policies, especially across England, Scotland, Wales, and Northern Ireland. Regional variations may lead to different costs, influencing patient access.

Additionally, online pharmacies are emerging as popular alternatives, providing access points that can challenge traditional purchasing methods. This shift is important for patients who require consistent medication without interruptions. Understanding the local access options is crucial. Pharmacists can guide patients through the NHS prescription process or offer advice on private purchasing when coverage is inadequate.

To navigate these variations effectively, increasing awareness of access options can empower patients. This not only aids in managing health but also helps patients understand the uniphyllin market access landscape, including uniphyllin NHS prescription costs and potential pricing discrepancies.

Comparable Medicines and Preferences

Uniphyllin isn't the only medication making waves in respiratory care. Other methylxanthines like aminophylline and dyphylline fill similar roles, although they differ in dosing protocols and management strategies. When evaluating alternatives, it's important to consider patient preferences and treatment efficacy.

Inhaled therapies such as long-acting beta-agonists (LABA) and inhaled corticosteroids stand as first-line treatments for respiratory issues. Drawing up a checklist comparing uniphyllin with these alternatives can simplify discussions with patients. Key factors include:

• Efficacy
• Dosing schedules
• Side effect profiles

Engaging patients in shared decision-making is essential. The trend towards more innovative inhaler devices not only enhances convenience but also boosts adherence. Ultimately, understanding uniphyllin's place within the broader spectrum of respiratory treatments, and encouraging open conversation about patient preferences, can lead to more tailored treatment plans.

FAQ Section

Common Questions about Uniphyllin

What conditions does uniphyllin treat? Uniphyllin primarily treats asthma and COPD, particularly for patients experiencing inadequate control with other bronchodilators.

Can uniphyllin cause side effects? Yes, while low to moderate side effects are common, including nausea, headache, and insomnia, serious effects are less likely but should be monitored.

Is uniphyllin a steroid? No, uniphyllin is categorised as a bronchodilator in the xanthine class, not a steroid.

How should I take uniphyllin? It’s advisable to take uniphyllin on an empty stomach and to follow healthcare provider instructions strictly. Capsules should be swallowed whole.

Guidelines for Proper Use

Maximising the therapeutic benefits of uniphyllin hinges on its proper use. Pharmacies play a crucial role in educating patients about their prescriptions, emphasizing adherence strategies, potential side effects, and the importance of regular follow-up appointments for serum level monitoring.

Encouraging open discussions about any side effects can significantly enrich the patient experience. Additionally, NHS patient portals provide vital resources, offering medication information and tools for tracking side effects or prescription refills.

This comprehensive approach not only aids in effective medication management but also fosters a supportive relationship between pharmacists and patients, ultimately enhancing patient engagement and safety. Key guidelines for uniphyllin usage include:

• Maintain thorough medication tracking.
• Consult providers regularly about any side effects.
• Engage with patient portals for additional support.

City	Region	Delivery time
London	Greater London	5–7 days
Birmingham	West Midlands	5–7 days
Manchester	North West	5–7 days
Glasgow	Scotland	5–7 days
Leeds	West Yorkshire	5–7 days
Newcastle	North East	5–7 days
Sheffield	South Yorkshire	5–7 days
Bristol	South West	5–7 days
Cardiff	Wales	5–9 days
Nottingham	East Midlands	5–9 days
Southampton	South East	5–9 days
Leicester	East Midlands	5–9 days